Description: PHARMACEUTICAL EFFECTS: Gastro-intestinal Action:PASPERAN seems to sensitise tissues to the action of acetylcholine. PASPERAN increases the number, strength and activity of gastric antral contractions and also producing an increase in the strength of duodenal contractions.These changes increase the speed of gastric emptying and reduce reflux from the duodenum and the stomach into the oesophagus. Which has …
Description: CLINICAL PHARMACOLOGY Diphenoxylate is rapidly and extensively metabolized in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is the major metabolite in the blood and biologically active. An average of 14% of the drug plus its metabolites were excreted in the urine and 49% in the faeces over a 4-day period. Urinary excretion …
Description: CLINICAL PHARMACOLOGY:Ketotifen is a relatively selective, non-competitive histamine antagonist(Hydrogen (H1)-receptor) and mast cell stabilizer. Ketotifen inhibits the release of mediators from cellsinvolved in hypersensitivity reactions. Decreased chemotaxis and activation of eosinophils has also beendemonstrated. INDICATIONS AND USAGE:ASTOMED is indicated for the temporary prevention of itching of the eye due to allergic conjunctivitis.CONTRAINDICATIONS:ASTOMED is contraindicated …
Description: Properties :Bisacodyl is stimulant laxative . It exerts its action along pipe colic, it increases the testinalmotility, and its secretion to water, electrolytes and proteins . Indications :Laxamid is used for the symptomatic treatment of constipation and the preparation toradiographic examination, colon and rectum endoscopy . Contraindications : * Acute abdominal pain . * rectal …
Description: Properties :Acyclovir is an antiviral agent which is highly active in vitro against herpes simplex virus (HSV) typesI and II and varicella zoster virus . Toxicity to mammal cells is low .Acyclovir is phosphorylated her entry into herps – infected cells Acyclovir triphosphate e firststep in this process is dependent on the presence of …
Description: Clinical Pharmacology : Folic Acid acts on megaloblastic bone marrow to produce a normoblastic marrow. In man, an exogenous source of folate is required for nucleoprotein synthesis and the maintenance of normal erythropoiesis. Folic Acid is the precursor of tetrahydroFolic Acid, which is involved as a cofactor for transformylation reactions in the biosynthesis of …
Description: Pharmacological Classifications NONSTEROIDAL ANTI-INFLAMMATORY DRUGS Indications: Ampoules for IM use: The ampoules are effective in acute forms of pain, including renal colic, exacerbations of osteo- and rheumatoid arthritis, acute back pain, acute gout, acute trauma and fractures, and post-operative pain. Ampoules used in intravenous infusion: For treatment or prevention of post-operative pain in the …
Description: INDICATIONS: Epilepsy: Primary generalized epilepsy (petit mall absences, various forms of myoclonic and tonic clonic grand mall seizures) Partial (focal) epilepsy either alone or as adjuvant therapy Mania: For the treatment of Mania where other therapy has proved inadequate or is inappropriate WARNINGS AND PRECAUTIONS: Female children/Female adolescents/Women of childbearing potential/Pregnancy: Valproate should not be used …
Description: Properties :Halomed is a potent neuroleptic belonging to the butyrophenones and has the following properties :– excellent antipsychotic action .– wide safety range .– leaves the patient alert , does not over sedation .– virtually free of autonomic effects , e.g. orthostatic hypotension .– highly effective in nausea and vomiting .– rapid onset of action …
Description: PROPERTIES:Isosorbide dinitrate acts as a peripheral and coronary vasodilator which causes relaxation of smooth muscle (producing a vasodilatory effect on both peripheral arteries and veins), lowering of peripheral arterial blood pressure, decreased venous return to the heart and decreased left ventricular filling pressure (preload).PHARMACOKINETIC PROPERTIES:Isosorbide dinitrate is readily absorbed from the oral mucosa and also following …
