LOTAN
Description: CLINICAL PHARMACOLOGY Diphenoxylate is rapidly and extensively metabolized in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is the major metabolite in the blood and biologically active. An average of 14% of the drug plus its metabolites were excreted in the urine and 49% in the faeces over a 4-day period. Urinary excretion …